Could the sweetened drinks we're consuming be making us feel a little more anxious? A 2022 study looking at the effects of the artificial sweetener aspartame on mice suggests that it's a possibility that's worth investigating further.
So 15% for a 60 kilogram human, on the lower end, would be the daily recommended amount for a 9 kilogram creature. A mouse weighs around 0.025 kilograms. So, that amount for the mice is for something 360 times larger.
Obviously it’s more complicated than that with differing metabolisms and the like, but as a rough estimate, wow. That’s a lot.
I’m baffled by your willingness to elaborate at length about this, but not read the article where this is explained. Misinforming everyone in the process.
When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA’s recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.
Just in case you missed it, we discussed below that that’s the 15% daily recommended amount for a human. That they gave to the mice. A creature several hundred times smaller.
When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA’s recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.
Can you cite your sources? This excerpt from the published article suggests you’re wrong:
The FDA recommended maximum DIV for aspartame for humans is 50 mg/kg (33). Based on allometric conversion utilizing pharmacokinetic and body surface area parameters (43), the mouse equivalent of the human DIV is 615 mg/kg/d. Therefore, the male mice received a daily aspartame dose equivalent to 14.0%, 7.0%, and 3.5% of the FDA recommended human DIV, and the females received a dose equivalent to 15.5%, 7.7%, and 3.9% of the human DIV.
The article actually states how much. 15% of the daily recommended amount.
There’s a daily recommended amount for mice? Or was that 15% of the recommended amount for humans, which would be massive for mice?
The daily recommended amount is usually given in dosage mass per body mass, e.g. 5mg per kg of body mass.
Although in humans, for labeling on retail products, they usually label it for a roughly average human.
It’s the equivalent of the human daily dose. So adjusted for body weight. Loosely translated, it would be 15% of the daily recommended dose for mice.
15% of humans recommended amount. It’s in the article.
Actually no, the keyword is equivalent, so adjusted for body weight.
Ah I think you’re right.
So 15% for a 60 kilogram human, on the lower end, would be the daily recommended amount for a 9 kilogram creature. A mouse weighs around 0.025 kilograms. So, that amount for the mice is for something 360 times larger.
Obviously it’s more complicated than that with differing metabolisms and the like, but as a rough estimate, wow. That’s a lot.
I’m baffled by your willingness to elaborate at length about this, but not read the article where this is explained. Misinforming everyone in the process.
I stand corrected! That’s a ridiculously small amount!
Just in case you missed it, we discussed below that that’s the 15% daily recommended amount for a human. That they gave to the mice. A creature several hundred times smaller.
So you were right in the first place.
No, it’s the equivalent dose.
Can you cite your sources? This excerpt from the published article suggests you’re wrong: