Since the topic adventure paths came up here recently I thougt I’d ask y’all what your best advice is when it comes to running them.
The thing I learned was read the whole thing. Best is if you manage to do this before the first session so you can help your players engeneer their background story along the adventure path.
It doesn’t answer your question, but one thing I really love about the official Paizo APs is they come with a player’s guide, giving them advice on what they can do to fit their backgrounds into the story better, as well as general background information that they should be aware of.