I’ll go first. Mine is the instant knockout drug. Like Dexter’s intramuscular injection that causes someone to immediately lose consciousness. Or in the movie Split where there’s the aerosol spray in your face that makes you instantly unconscious. Or pretty much any time someone uses chloroform.
In my tabletop RPG campaigns I always make it a point for my characters to have at least one living parent, and usually two. These games are always so full of haunted orphans whose villages were burned to the ground or whatever.