I think it will work. I use profiles to “bootstrap” firefox configurations whenever I do a new install so I don’t need to go manually configure settings and install extensions. If Librewolf settings are done on the profile level, I’d think it would be identical if moved over to FF, unless they are different versions and there are settings that exist in one and don’t on the other.

I think librewolf only changes some settings in your user profile. So if you were to copy it to Firefox, it would be exactly the same as Librewolf. But keep in mind that updates to Firefox might require an updated Librewolf profile that you wouldn’t be getting. So I guess you would slowly lose all the Librewolf changes. But like I said, I’m not sure, so I could be wrong.